Here's a look at those games:
Oct. 3, 2004 vs. NY Giants: Midway through the third quarter, Favre suffered a concussion after being knocked to the ground by defensive lineman William Joseph. Favre wobbled out of the game for two plays but returned to throw a 28-yard touchdown pass to wide receiver Javon Walker on fourth down to give the Packers a brief 7-0 lead.
That, however, was the last time Favre would see the field in the 14-7 setback at Lambeau Field.
Backup Doug Pederson played the rest of the game at quarterback for the Packers with the exception of the game's final play when Craig Nall completed a pass. Pederson was 7 of 17 for 86 yards while Nall's lone attempt was a 24-yard completion.
Sept. 26, 2004 at Indianapolis: Favre missed the final possession of a 45-31 loss at Indianapolis after getting kneed in the back of the leg in the fourth quarter by Colts' defensive end Dwight Freeney.
Pederson took over and went 4-of-6 for 34 yards and one interception.
Despite that injury and the revelation that his left shoulder was aching, Favre made his 193rd consecutive start the next week against the Giants at Lambeau Field.
Oct. 20, 2002 vs. Washington: Favre was forced from the game early in the third quarter when he suffered a sprained to the lateral collateral ligament in his left while being sacked by the Redskins' LaVar Arrington in a 30-9 win at Lambeau Field.
Pederson entered with the Packers' comfortably ahead and kept the lead by leading the team to two field goals and one touchdown in five series. He finished 9 of 15 for 78 yards with no touchdowns or interceptions.
A test the day after the game revealed Favre had no major damage to his knee and he started the Packers next game 15 days later (thanks to a bye) vs. Miami in Green Bay.
Nov. 12, 2000 at Tampa Bay: A foot sprain inflicted by Warren Sapp sent Favre to the sidelines and second-year man Matt Hasselbeck into what would be a 20-15 loss to the Buccaneers.
The Boston College product finished the game and was 9-of-18 for 93 yards with a touchdown and no interceptions. His TD pass -- a 27-yard strike to tight end Bubba Franks as the result of a fake field goal -- gave the Pack a short-lived 15-14 lead early in the fourth quarter.
Dec. 24, 1995 vs. Pittsburgh: Jim McMahon to the rescue! A shaken up Favre had miss two plays late in the season-finale at Lambeau Field. The recently-signed McMahon completed a pass -- his first with the team -- that got the Packers within field goal range. Chris Jacke converted the 3-pointer and the Packers pulled off a 24-19 NFC Central Division-clinching win.
Nov. 5, 1995 at Minnesota: A severly sprained ankle knocked Favre out of a 27-24 loss at Minnesota.
He was first replaced by Ty Detmer but Detmer was eventually KO'd by a thumb injury. Third-stringer T.J. Rubley then entered the game and threw a late interception which doomed the Packers.
Oct. 20, 1994 at Minnesota: Favre went down with a hip injury early in a 13-10 loss at Minnesota. Left-hander Mark Brunell came on and went 11 of 24 and scored on a 5-yard run in the future Jaguar's most extensive playing time in Green Bay.
Early 1992 season: Favre left a game because of an injury early in his career but his sub -- Don Majkowski -- did not need to throw a pass.