Henderson, entering his 12th season, has played in 190 of the Packers' last 192 games, including the postseason. He has played 86 career regular season games at Lambeau Field, second in team history behind Brett Favre (102).
The Packers inserted running backs Samkon Gado and Noah Herron at fullback position during practice on Monday behind Vonta Leach. Ben Brown is the only other true fullback in the Packers training camp.
"You'd like William (to be back); he's been around here a long time," offensive coordinator Jeff Jagodzinski said. "He'll be back. When guys go down, you have to have other guys step up. That's true at any position."
There is a possibility that the Packers will go with two running backs, rather than the traditional running back-fullback combination. Gado, who hasn't played fullback since high school, says that it not necessary to have a bigger back in the team's new zone-blocking offense.
"You don't need to be a bruiser in this system; you just need to be able to be versatile," Gado said. "I think pretty much the fullback is a glorified tailback in this offense. You need to have more versatility than fullbacks in most other offenses."